We offer nutritional solutions for liver support. Discover how to create products that counteract the development of fatty liver.
Fatty liver disease is often associated with alcohol abuse. But, in fact, non-alcoholic fatty liver disease (NAFLD) has become the most common liver ailment worldwide. It comprises a spectrum of conditions, ranging from simple steatosis to non-alcoholic steatohepatitis and cirrhosis of the liver. In western countries, it is also the most rapidly increasing cause of liver cancer.
This serious condition results from an imbalance between fat uptake, oxidation and export. It is commonly associated with obesity, diabetes and metabolic syndrome. Currently, there are no efficient means of treating steatosis or steatohepatitis. So, early prevention and liver support are essential.
What is non-alcoholic fatty liver disease? In short, NAFLD is characterized by the excess accumulation of hepatic fat –not caused by excessive alcohol consumption. That means a concentration of lipid droplets in more than 5% of liver cells in people who drink little or no alcohol. Today, NAFLD is one of the most common liver diseases worldwide and can progress to non-alcoholic steatohepatitis (NASH).
The figures are alarming: according to estimates, up to 39% of people in western countries and some regions of China have developed NAFLD and up to 5% suffer from NASH. Every third NASH patient has advanced fibrosis, and every fifth develops cirrhosis. Many factors lead to the development of NAFLD, such as excessively fatty diets combined with insulin resistance, oxidative stress and innate immunity. It is associated with obesity, type 2 diabetes, dyslipidemia, metabolic syndrome and cardiovascular disease.
Most NAFLD patients are advised to eat healthily, increase their physical activity and, in many cases, lose weight. This improves liver enzyme levels and the organ’s overall histology. The situation is more alarming for NASH patients: there is no proven pharmacotherapeutic treatment. NASH patients with liver failure and/or hepatocellular carcinoma (HCC) are candidates for liver transplantation. This is why early prevention with lifestyle changes and proper nutrition and supplements is crucial.
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